Anthony M Downs Selected Research

Trihexyphenidyl (Artane)

1/2022	Blockade of M4 muscarinic receptors on striatal cholinergic interneurons normalizes striatal dopamine release in a mouse model of TOR1A dystonia.
1/2019	Trihexyphenidyl rescues the deficit in dopamine neurotransmission in a mouse model of DYT1 dystonia.

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Anthony M Downs Research Topics

Disease

5	Dystonia (Limb Dystonia) 01/2022 - 01/2019
2	Dystonia musculorum deformans type 1 01/2022 - 01/2019
1	Substance Withdrawal Syndrome (Withdrawal Symptoms) 01/2022
1	Dystonic Disorders (Writer's Cramp) 01/2021
1	Dopa-responsive Dystonia 01/2021
1	Sepsis (Septicemia) 04/2020
1	Bradycardia 05/2016
1	Myocardial Infarction 05/2015
1	Infarction (Infarctions) 05/2015

Drug/Important Bio-Agent (IBA)

4	Cholinergic Agents (Cholinergics)IBA 01/2022 - 05/2016
4	Dopamine (Intropin)FDA LinkGeneric 01/2022 - 01/2019
2	Trihexyphenidyl (Artane)FDA LinkGeneric 01/2022 - 01/2019
2	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 01/2022 - 01/2019
1	2- methyl- 4- carboxy- 5- hydroxy- 3,4,5,6- tetrahydropyrimidineIBA 01/2022
1	Adrenergic Receptors (Adrenergic Receptor)IBA 01/2022
1	Muscarinic M4 ReceptorIBA 01/2022
1	Neurotransmitter Agents (Neurotransmitter)IBA 01/2021
1	Proteins (Proteins, Gene)FDA Link 01/2021
1	Vesicular Acetylcholine Transport Proteins (Vesicular Acetylcholine Transporter)IBA 04/2020
1	Acetylcholine (Acetylcholine Chloride)FDA Link 04/2020
1	Choline O-Acetyltransferase (Choline Acetyltransferase)IBA 04/2020
1	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 01/2019
1	Pharmaceutical PreparationsIBA 01/2019
1	Dihydroxyphenylalanine (Dopa)IBA 01/2019
1	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/2019
1	Atenolol (Tenormin)FDA LinkGeneric 05/2016
1	NeuropeptidesIBA 05/2015

Therapy/Procedure

2	Therapeutics 01/2022 - 10/2019
1	Ligation 04/2020
1	Punctures 04/2020